Chromosomal Instability: Mad2 beyond the Spindle Checkpoint
نویسندگان
چکیده
منابع مشابه
Chromosomal Instability: Mad2 beyond the Spindle Checkpoint
What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.
متن کاملThe Mad1-Mad2 balancing act--a damaged spindle checkpoint in chromosome instability and cancer.
Cancer cells are commonly aneuploid. The spindle checkpoint ensures accurate chromosome segregation by controlling cell cycle progression in response to aberrant microtubule-kinetochore attachment. Damage to the checkpoint, which is a partial loss or gain of checkpoint function, leads to aneuploidy during tumorigenesis. One form of damage is a change in levels of the checkpoint proteins mitotic...
متن کاملA direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment.
The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation by delaying entry into anaphase until all sister chromatids have become bi-oriented. A key component of the SAC is the Mad2 protein, which can adopt either an inactive open (O-Mad2) or active closed (C-Mad2) conformation. The conversion of O-Mad2 into C-Mad2 at unattached kinetochores is thought to be a key step in ac...
متن کاملWaiting for Anaphase Mad2 and the Spindle Assembly Checkpoint
arrest in mitosis following drug-induced inhibition of spindle microtubule assembly. These identified two trios of nonessential genes in budding yeast, Bub1-3, for budding uninhibited by benzimidazole and Mad1-3, for mi-totic arrest deficient. To these has been added Mps1. This kinase is essential for duplication of the microtubule nucleation sites (called spindle pole bodies in yeast), but mut...
متن کاملThe Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint
BACKGROUND The spindle assembly checkpoint (SAC) imparts fidelity to chromosome segregation by delaying anaphase until all sister chromatid pairs have become bipolarly attached. Mad2 is a component of the SAC effector complex that sequesters Cdc20 to halt anaphase. In prometaphase, Mad2 is recruited to kinetochores with the help of Mad1, and it is activated to bind Cdc20. These events are linke...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2012
ISSN: 0960-9822
DOI: 10.1016/j.cub.2012.02.059